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珞珈讲坛第284讲:Innate immunity to cytosolic bacteria: pyroptosis and beyond
时间:2019-01-09 14:51:45 阅读量:
珞珈讲坛第284讲
时 间:2019年1月9日(周三)15 :00
地 点:武汉大学樱顶老图书馆
主讲人:邵峰教授 中国科学院院士
题 目:Innate immunity to cytosolic bacteria: pyroptosis and beyond
主讲人简介:
  邵峰博士1996年毕业于北京大学技术物理系,1999年于中科院生物物理所获得硕士学位,2003年美国密西根大学生物化学系获得博士学位,现为北京生命科学研究所资深研究员、科研副所长。
  邵峰博士长期研究病原细菌和宿主相互作用机理,在致病菌毒力机制以及抗细菌天然免疫方向均取得系列重要原创性发现:包括发现细菌内毒素(LPS)、鞭毛以及病原菌三型分泌系统的胞内天然免疫受体(组装形成炎症小体复合物),进而揭示和阐明了这些受体下游的炎性caspase通过剪切活化Gasdermin D(GSDMD)蛋白诱导细胞焦亡的确切分子机制;这些发现为败血症药物和细菌疫苗的研发提供了新的理论基础,其中有关Gasdermin家族蛋白的鉴定和机制的阐述也将细胞焦亡的概念重新定义为由Gasdermin家族介导的细胞程序性坏死。邵峰博士已发表学术论文70多篇,总引用9,000次,2005年回国后以通讯作者在《自然》、《科学》和《细胞》三大杂志发表研究论文13篇;获得多项国际和国内重要奖项,包括周光召杰出青年基础科学奖、HHMI国际青年科学家奖、国际蛋白质学会鄂文西格青年科学家奖、吴阶平-保罗杨森基础医学奖以及何梁何利基金科学与技术奖等,入选北京市海外高层次人才工程、国家百千万人才工程、首届“北京学者”以及国家万人计划(领军人才),为享受国务院特殊津贴专家,2015年当选为中科院院士和EMBO的外籍成员,2016年当选为美国微生物学院院士。
Brief Introduction of Professor Feng Shao
  Dr. Feng Shao graduated from the School of Physics at Peking University and received his bachelor degree in Applied Chemistry in 1996, received his master degree in Molecular Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing in 1999, and received his Ph.D. in Biological Chemistry, University of Michigan Medical School, USA. Currently, he is a senior investigator and deputy director at National Institute of Biological Sciences, Beijing.
  Dr. Feng Shao’s laboratory is interested in studying the interaction mechanisms of Bacterial pathogens and the host. His laboratory work has led to several a series of important and original discoveries in the pathogenic virulence mechanism and anti-bacterial natural immunity. For instance, the laboratory found that bacterial endotoxin (LPS), flagella and intracellular secretion system of pathogens innate immune receptors (assembled to form inflammatory corpuscle complexes), which in turn reveals and elucidates the exact molecular mechanisms of which inflammatory caspase downstream of these receptors induces cell pyroptosis by shearing and activating Gasdermin D (GSDMD) proteins; these findings provide a new theoretical basis for the development of the sepsis pharmaceuticals and bacterial vaccines, and the elaboration of the identification and mechanism of the Gasdermin family also redefines the concept of cell pyroptosis into a programmed necrosis mediated by the Gasdermin family. Dr. Shao Feng has published more than 70 academic papers, which have been quoted by 9,000 times in total. After returning to China in 2005, he published 13 research papers in the three major journals of Nature, Science and Cell. He won several international and domestic important awards include Zhou Guangzhao Outstanding Youth Foundation Science Award, HHMI International Young Scientist Award, International Protein Society Evansig Young Scientist Award, Wu Jieping & Paul Yangsen Basic Medicine Award, and the He Liang & He Li Fund Science and Technology Award. He was also selected into the High-level Talent Project, National Talent Project, first “Beijing Scholar” and National 10,000 Talents Plan (leading talent), expert for the special allowance of the State Council. He was elected as an academician of the Chinese Academy of Sciences and a foreign member of EMBO in 2015, and was elected as the fellow of the College of Microbiology of United States in 2016.